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eMediNexus 27 May 2021
Bhatt D.L. et al. studied the efficacy and safety of sotagliflozin, a sodium–glucose cotransporter 2 inhibitor, in preventing cardiovascular events in patients with diabetes with chronic kidney disease with or without albuminuria.
They conducted a multicenter, double-blind trial including patients with type 2 diabetes mellitus (glycated hemoglobin level, ≥7%), chronic kidney disease (estimated glomerular filtration rate, 25 to 60 ml/minute/1.73 m2 of body-surface area), and risks for cardiovascular disease.
The patients were randomized to receive either sotagliflozin or placebo.
The primary end-point was the assessment of- a composite of the total number of deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for heart failure.
The observations of the study were-
The rate of primary end-point events-
The rate of deaths from cardiovascular causes-
Thus the researchers concluded that in patients with diabetes and chronic kidney disease, with or without albuminuria, sotagliflozin shows a lower risk of the composite of deaths from cardiovascular causes, hospitalizations for heart failure, and urgent visits for heart failure than placebo but is associated with more adverse events.
Source-Bhatt DL, Szarek M, Pitt B, Cannon CP, Leiter LA, McGuire DK. et al. Terlipressin plus Albumin for the Treatment of Type 1 Hepatorenal Syndrome, N Engl J Med, 2021;384(9):818-828. doi: 10.1056/NEJMoa2008290.
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